One of the main causes of the severe neonatal illness and infant mortality is a syndrome of endogenous intoxication, occuring in acute pneumonia, hemolytic disease, hyperbilirubinemia, septic and other complications, when even new antibiotics are helpless. Implementation of detoxification procedures by generally accepted methods of efferent therapy (hemosorbtion and plasmapheresis, - gravity, apparatus or packed) to newborns, especially to premature babies, faces several technical and methodical problems.